T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.

doi:10.1172/JCI138230

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Article

T cell protein tyrosine phosphatase protects intestinal barrier function by restricting epithelial tight junction remodeling.

The Journal of clinical investigation - 1 Sept 2021

Marchelletta Ronald R, Krishnan Moorthy, Spalinger Marianne R, Placone Taylaur W, Alvarez Rocio, Sayoc-Becerra Anica, Canale Vinicius, Shawki Ali, Park Young Su, Bernts Lucas Hp, Myers Stephen, Tremblay Michel L, Barrett Kim E, Krystofiak Evan, Kachar Bechara, McGovern Dermot Pb, Weber Christopher R, Hanson Elaine M, Eckmann Lars, McCole Declan F

Abstract excerpt

Genome-wide association studies revealed that loss-of-function mutations in protein tyrosine phosphatase non-receptor type 2 (PTPN2) increase the risk of developing chronic immune diseases, such as inflammatory bowel disease (IBD) and celiac disease. These conditions are associated with increased intestinal permeability as an early etiological event. The aim of this study was to examine the consequences of...

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Identifiers

PMID: 34623320
DOI: 10.1172/JCI138230
PMCID: PMC8409587

Genes

PTPN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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