Article
The PTPN2 rs1893217 IBD risk allele increases susceptibility to AIEC invasion by a JAK-STAT-CEACAM6 axis.
Gut microbes - 1 Dec 2025
Chatterjee Pritha, Canale Vinicius, King Stephanie J, Shawki Ali, Lei Hillmin, Santos Alina N, Haddad Michael, Gries Casey, McGovern Dermot P B, Borneman James, McCole Declan F
Abstract excerpt
Inflammatory bowel disease (IBD) patients often exhibit expansion of the gut pathobiont, adherent-invasive E. coli (AIEC). Loss of activity of the IBD susceptibility gene, protein tyrosine phosphatase type 2 (PTPN2), causes gut microbiota dysbiosis in IBD patients, while Ptpn2 knock-out (Ptpn2-KO) mice display AIEC expansion. CEACAM6, a host cell surface glycoprotein, is exploited by AIEC to attach to and enter...
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