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A Computational Systems Biology Approach Identifies SLUG as a Mediator of Partial Epithelial-Mesenchymal Transition (EMT).

Cells, tissues, organs - 1 Jan 2022

Subbalakshmi Ayalur R, Sahoo Sarthak, Biswas Kuheli, Jolly Mohit Kumar

Abstract excerpt

Epithelial-mesenchymal plasticity comprises reversible transitions among epithelial, hybrid epithelial/mesenchymal (E/M) and mesenchymal phenotypes, and underlies various aspects of aggressive tumor progression such as metastasis, therapy resistance, and immune evasion. The process of cells attaining one or more hybrid E/M phenotypes is termed as partial epithelial mesenchymal transition (EMT). Cells in hybrid...

Topics

Humans
Systems Biology
Epithelial-Mesenchymal Transition
Phenotype
Neoplasms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33567424
DOI: 10.1159/000512520

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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