Article
The Epithelial-Mesenchymal Transition and Cancer Stem Cells: Functional and Mechanistic Links
3 Feb 2015
Abstract excerpt
The epithelial-mesenchymal transition (EMT) is a highly conserved cellular process that transforms epithelial cells into mesenchymal cells; EMT is involved in normal embryogenesis and tissue repair and contributes to tumor progression, including tumor metastasis, therapy resistance and disease recurrence. Cancer stem cells (CSCs) represent a fraction of undifferentiated cancer cells that exhibit stem cell-like...
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