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Network Assisted Analysis of<i>De Novo</i>Variants Using Protein-Protein Interaction Information Identified 46 Candidate Genes for Congenital Heart Disease

2021-12-02

Abstract excerpt

De novo variants (DNVs) with deleterious effects have proved informative in identifying risk genes for early-onset diseases such as congenital heart disease (CHD). A number of statistical methods have been proposed for family-based studies or case/control studies to identify risk genes by screening genes with more DNVs than expected by chance in Whole Exome Sequencing (WES) studies. However, the statistical power...

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Identifiers and source

Literature Corpus work
31624b10-2b0c-5af4-92ca-bd4226a92c7e
DOI
10.1101/2021.11.30.21267069
Open publication

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