Article

Integration of Protein Interactome Networks with Congenital Heart Disease Variants Reveals Candidate Disease Genes

2021-01-05

Abstract excerpt

<h4>SUMMARY</h4> Congenital heart disease (CHD) is present in 1% of live births, yet identification of causal mutations remains a challenge despite large-scale genomic sequencing efforts. We hypothesized that genetic determinants for CHDs may lie in protein interactomes of GATA4 and TBX5, two transcription factors that cause CHDs. Defining their interactomes in human cardiac progenitors via affinity purification-...

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Literature Corpus work: 7911c747-a048-52ad-b813-7a531883510d
DOI: 10.1101/2021.01.05.423837

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