Article

M-DATA: A Statistical Approach to Jointly Analyzing <i>De Novo</i> Mutations for Multiple Traits

2021-05-23

Abstract excerpt

Recent studies have demonstrated that multiple early-onset diseases have shared risk genes, based on findings from de novo mutations (DNMs). Therefore, we may leverage information from one trait to improve statistical power to identify genes for another trait. However, there are few methods that can jointly analyze DNMs from multiple traits. In this study, we develop a framework called M-DATA ( M ulti-trait framew...

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Literature Corpus work: a278afcb-5073-51f8-867b-7101f39c9a37
DOI: 10.1101/2021.05.22.21257421

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