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<i>APOE</i>and<i>TREM2</i>variants differentially influence glial fibrillary acidic protein and neurofilament light in plasma of UK Biobank participants

2025-02-25

Abstract excerpt

Plasma levels of protein biomarkers glial fibrillary acidic protein (GFAP) and neurofilament light (NEFL) are key dementia biomarkers, but it is unclear how risk genes for Alzheimer’s disease (AD) influence levels of these biomarkers. We investigated the association of the established high-effect variants for AD in APOE and TREM2 with these biomarkers, using data from over 50,000 participants from the UK Biobank (...

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Literature Corpus work
3128c347-8ec7-5887-98bf-0b00845ff5e3
DOI
10.1101/2025.02.24.25322783
Open publication

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