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Article

Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Feb 2015

Young Howard S, Ceholski Delaine K, Trieber Catharine A

Abstract excerpt

The sarcoplasmic reticulum (SR) calcium pump (SERCA) and its regulator phospholamban are required for cardiovascular function. Phospholamban alters the apparent calcium affinity of SERCA in a process that is modulated by phosphorylation via the β-adrenergic pathway. This regulatory axis allows for the dynamic control of SR calcium stores and cardiac contractility. Herein we focus on hereditary mutants of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Source

Identifiers

PMID: 25563649
DOI: 10.1139/bcb-2014-0080

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy.PMID 25563649Read ↗

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