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Article

Comparison of the structure and function of phospholamban and the arginine-14 deficient mutant associated with dilated cardiomyopathy.

PloS one - 1 Jan 2014

Hughes Eleri, Middleton David A

Abstract excerpt

Phospholamban (PLB) is a pentameric protein that plays an important role in regulating cardiac contractility via a reversible inhibitory association with the sarcoplasmic reticulum Ca2+ATPase (SERCA), the enzyme responsible for maintaining correct calcium homeostasis. Here we study the functional and biophysical characteristics of a PLB mutant associated with human dilated cardiomyopathy (DCM), with a deletion of...

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Identifiers

PMID: 25225809
DOI: 10.1371/journal.pone.0106746
PMCID: PMC4165587

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Click a neighbor to travelStep 1 · 12 closest

Comparison of the structure and function of phospholamban and the arginine-14 deficient mutant associated with dilated cardiomyopathy.PMID 25225809Read ↗

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.Semantic proximity Read ↗

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Dilated cardiomyopathy variant R14del increases phospholamban pentamer stability, blunting dynamic regulation of cardiac calcium handlingSemantic proximity Read ↗

Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.Semantic proximity Read ↗

Deception in simplicity: hereditary phospholamban mutations in dilated cardiomyopathy.Semantic proximity Read ↗

Hydrophobic imbalance in the cytoplasmic domain of phospholamban is a determinant for lethal dilated cardiomyopathy.Semantic proximity Read ↗

Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure.Semantic proximity Read ↗

Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump.Semantic proximity Read ↗

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.Semantic proximity Read ↗

Tuning the structural coupling between the transmembrane and cytoplasmic domains of phospholamban to control sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) function.Semantic proximity Read ↗

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and humanSemantic proximity Read ↗

Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathySemantic proximity Read ↗

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