Article
Dysfunctional conformational dynamics of protein kinase A induced by a lethal mutant of phospholamban hinder phosphorylation.
Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2015
Kim Jonggul, Masterson Larry R, Cembran Alessandro, Verardi Raffaello, Shi Lei, Gao Jiali, Taylor Susan S, Veglia Gianluigi
Abstract excerpt
The dynamic interplay between kinases and substrates is crucial for the formation of catalytically committed complexes that enable phosphoryl transfer. However, a clear understanding on how substrates modulate kinase structural dynamics to control catalytic efficiency is still missing. Here, we used solution NMR spectroscopy to study the conformational dynamics of two complexes of the catalytic subunit of the...
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