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Article

Lethal, hereditary mutants of phospholamban elude phosphorylation by protein kinase A.

The Journal of biological chemistry - 3 Aug 2012

Ceholski Delaine K, Trieber Catharine A, Holmes Charles F B, Young Howard S

Abstract excerpt

The sarcoplasmic reticulum calcium pump (SERCA) and its regulator, phospholamban, are essential components of cardiac contractility. Phospholamban modulates contractility by inhibiting SERCA, and this process is dynamically regulated by β-adrenergic stimulation and phosphorylation of phospholamban. Herein we reveal mechanistic insight into how four hereditary mutants of phospholamban, Arg(9) to Cys, Arg(9) to...

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Identifiers

PMID: 22707725
DOI: 10.1074/jbc.M112.382713
PMCID: PMC3411000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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