Article

Power, false discovery rate and Winner’s Curse in eQTL studies

2017-10-25

Abstract excerpt

Investigation of the genetic architecture of gene expression traits has aided interpretation of disease and trait-associated genetic variants, however key aspects of expression quantitative trait (eQTL) study design and analysis remain understudied. We used extensive, empirically-driven simulations to explore eQTL study design and the performance of various analysis strategies. Across multiple testing correction m...

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Literature Corpus work: 30f74e8f-f614-5f60-9742-01abf1780f50
DOI: 10.1101/209171

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