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Article

Power, false discovery rate and Winner's Curse in eQTL studies.

Nucleic acids research - 14 Dec 2018

Huang Qin Qin, Ritchie Scott C, Brozynska Marta, Inouye Michael

Abstract excerpt

Investigation of the genetic architecture of gene expression traits has aided interpretation of disease and trait-associated genetic variants; however, key aspects of expression quantitative trait loci (eQTL) study design and analysis remain understudied. We used extensive, empirically driven simulations to explore eQTL study design and the performance of various analysis strategies. Across multiple testing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30189032
DOI: 10.1093/nar/gky780
PMCID: PMC6294523

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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