Article
Quantile regression for challenging cases of eQTL mapping.
Briefings in bioinformatics - 25 Sept 2020
Sun Bo, Chen Liang
Abstract excerpt
Mapping of expression quantitative trait loci (eQTLs) facilitates interpretation of the regulatory path from genetic variants to their associated disease or traits. High-throughput sequencing of RNA (RNA-seq) has expedited the exploration of these regulatory variants. However, eQTL mapping is usually confronted with the analysis challenges caused by overdispersion and excessive dropouts in RNA-seq. The...
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