Article

Pathogenic tau disrupts the cellular program that maintains neuronal identity

2021-03-07

Abstract excerpt

Neurons in human Alzheimer’s disease acquire phenotypes that are also present in various cancers, including over-stabilization of the cytoskeleton, nuclear pleomorphism, decondensation of constitutive heterochromatin, and aberrant activation of the cell cycle. Unlike in cancer, in which cell cycle activation drives tumor formation, activation of the cell cycle in post-mitotic neurons is sufficient to induce neuron...

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Literature Corpus work: d63bf582-3f64-5789-b7e0-edaeea0456d5
DOI: 10.1101/2021.03.05.434166

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