Article

Recent developments in the role of DNA damage response and understanding its implications for new therapeutic approaches in Alzheimer's disease

2023-01-01

Abstract excerpt

The underlying molecular mechanisms associated with sporadic Alzheimer's disease (AD), a progressive neurodegenerative disease, are not yet fully understood. Adult neurons are post-mitotic cells that may need to survive for as long as the lifespan of the organism itself, they are exposed to DNA damaging stimuli and depend on DNA repair mechanisms for their survival. It is reasonable to hypothesize that inadequate...

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Literature Corpus work: d30ba791-b8c1-59f4-b9d7-b777cbb4f02d
DOI: 10.1016/j.tma.2023.06.004

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