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Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitro

13 Apr 2022

Abstract excerpt

DNA double-strand break (DSB) is the most severe form of DNA damage and accumulates with age, in which cytoskeletal proteins are polymerized to repair DSB in dividing cells. Since tau is a microtubule-associated protein, we investigate whether DSB is involved in tau pathologies in Alzheimer's disease (AD). First, immunohistochemistry reveals the frequent coexistence of DSB and phosphorylated tau in the cortex of...

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PMID: 35418705
DOI: 10.1038/s42003-022-03312-0

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