Moderate Effects of the Arginine to Histidine R47H Variant of the Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) on Bone Structure in Male and Female Mice: Insights from the Four Core Genotypes mice

Abstract excerpt

<title>Abstract</title> <p> Background The Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) gene is expressed in cells of the hematopoietic lineage, like microglia and osteoclasts. A TREM2 gene variant known as TREM2-R47H is associated with an increased risk of developing Alzheimer’s disease (AD). Previous studies have shown sex-dimorphic bone and muscle consequences that are associated with the TREM2 v...

Topics

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• Bone and Bones
• Bone Density
• Gonads
• Models, Animal
• Organ Size
• Sex Characteristics
• Sex Chromosomes
• Y Chromosome

Identifiers and source

Literature Corpus work

30d555e5-bd3c-5593-9d1a-386d7e1764f1

DOI

10.21203/rs.3.rs-9076483/v1