Article

Using genome-wide association results to identify drug repurposing candidates

2022-09-09

Abstract excerpt

Drug repurposing may provide a solution to the substantial challenges facing de novo drug development. Given that 66% of FDA-approved drugs in 2021 were supported by human genetic evidence, drug repurposing methods based on genome wide association studies (GWAS), such as drug gene-set analysis, may prove an efficient way to identify new treatments. However, to our knowledge, drug gene-set analysis has not been te...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65a1c787-ad26-53d3-8d81-cad6badfc24f
DOI: 10.1101/2022.09.06.22279660

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Using genome-wide association results to identify drug repurposing candidatesDOI 10.1101/2022.09.06.22279660Read

Advancing the use of genome-wide association studies for drug repurposing.Semantic proximity Read

Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization StudiesSemantic proximity Read

Translating GWAS Findings Into Therapies For Depression And Anxiety Disorders: Drug Repositioning Using Gene-Set Analyses Reveals Enrichment Of Psychiatric Drug ClassesSemantic proximity Read

When GWAS meets the Connectivity Map: drug repositioning for seven psychiatric disordersSemantic proximity Read

Leveraging the genetics of psychiatric disorders to prioritize potential drug targets and compounds.Semantic proximity Read

Use of genome-wide association studies for drug repositioningSemantic proximity Read

Leveraging Genetic Correlations to Prioritize Drug Groups for Repurposing in Type 2 DiabetesSemantic proximity Read

A genetically supported drug repurposing pipeline for diabetes treatment using electronic health recordsSemantic proximity Read

An Integrated Knowledge Graph and Network Medicine Pipeline for Drug Repurposing: Benchmarking Across Human Diseases and Application to Amyotrophic Lateral SclerosisSemantic proximity Read

Gene-set analysis based on the pharmacological profiles of drugs to identify repurposing opportunities in schizophrenia.Semantic proximity Read

A Genetics-guided Integrative Framework for Drug Repurposing: Identifying Anti-hypertensive Drug Telmisartan for Type 2 DiabetesSemantic proximity Read

Leveraging the Genetics of Psychiatric Disorders to Prioritize Potential Drug Targets and CompoundsSemantic proximity Read