Article
A paternal bias in germline mutation is widespread in amniotes and can arise independently of cell division numbers.
eLife - 2 Aug 2022
de Manuel Marc, Wu Felix L, Przeworski Molly
Abstract excerpt
In humans and other mammals, germline mutations are more likely to arise in fathers than in mothers. Although this sex bias has long been attributed to DNA replication errors in spermatogenesis, recent evidence from humans points to the importance of mutagenic processes that do not depend on cell division, calling into question our understanding of this basic phenomenon. Here, we infer the ratio of...
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