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Amino acid substitutions involved in the adaptation of a novel highly pathogenic H5N2 avian influenza virus in mice

23 Sept 2016

Abstract excerpt

BACKGROUND: H5N2 avian influenza viruses (AIVs) can infect individuals that are in frequent contact with infected birds. In 2013, we isolated a novel reassortant highly pathogenic H5N2 AIV strain [A/duck/Zhejiang/6DK19/2013(H5N2) (6DK19)] from a duck in Eastern China. This study was undertaken to understand the adaptive processes that led enhanced replication and increased virulence of 6DK19 in mammals. 6DK19 was...

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PMID: 27663652
DOI: 10.1186/s12985-016-0612-5

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