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Article

The PB2 I714S mutation influenced mammalian adaptation of the H3N2 canine influenza virus by interfering with nuclear import efficiency and RNP complex assembly.

Emerging microbes & infections - 1 Dec 2024

Li Xueyun, Jia Tingting, Wang Kele, Wang Liangliang, Zhou Lijuan, Li Mao, Zhu Wenfei, Shu Yuelong, Chen Yongkun

Abstract excerpt

Avian influenza viruses (AIVs) are the origin of multiple mammal influenza viruses. The genetic determinants of AIVs adapted to humans have been widely elucidated, however, the molecular mechanism of cross-species transmission and adaptation of AIVs to canines are still poorly understood. In this study, two H3N2 influenza viruses isolated from a live poultry market (A/environment/Guangxi/13431/2018, GX13431) and...

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Identifiers

PMID: 39139051
DOI: 10.1080/22221751.2024.2387439
PMCID: PMC11328605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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