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Article

Amino acid mutations K54E and S154P in the neuraminidase attenuate H3N2 canine influenza virus in mice.

The Journal of general virology - 1 Feb 2026

Pan Xue, Shi Xiaona, Zhao Luxiang, Yan Dawei, Zhou Fan, Liu Qinfang, Yuan Chunxiu, Xu Bangfeng, Zhang Zhifei, Yan Minghao, Teng Qiaoyang, Li Zejun

Abstract excerpt

Dogs are considered mixing vessels for influenza viruses, posing a pandemic potential via viral reassortment. Our previous studies indicated that the avian-origin H3N2 canine influenza virus (A/canine/Zhejiang/1/2010, abbreviated C1) is virulent in canine and mice. Furthermore, we found that the HA and NA genes of C1 share a close genetic relationship with an H3N2 avian influenza virus (A/duck/Shanghai/06/2009,...

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Identifiers

PMID: 41719149
DOI: 10.1099/jgv.0.002223
PMCID: PMC12923156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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