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Article

Synergistic effects of PA (S184N) and PB2 (E627K) mutations on the increased pathogenicity of H3N2 canine influenza virus infections in mice and dogs.

Journal of virology - 20 May 2025

Xiao Xiangyu, Wang Xinrui, Xu Fengpei, Liang Yanting, Luo Yi, Li Shoujun, Zhou Pei

Abstract excerpt

As companion animals, dogs are susceptible to various subtypes of influenza A virus (IAV), with the H3N2 and H3N8 subtypes of canine influenza virus (CIV) stably circulating among canines. Compared to the H3N8 CIV, the H3N2 CIV is more widely prevalent in canine populations and demonstrates increased adaptability to mammals, potentially facilitating cross-species transmission. Therefore, a comprehensive...

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PMID: 40183583
DOI: 10.1128/jvi.01984-24
PMCID: PMC12090714

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