Article

Network expansion of genetic associations defines a pleiotropy map of human cell biology

2021-07-19

Abstract excerpt

Proteins that interact within molecular networks tend to have similar functions and when perturbed influence the same organismal traits. Interaction networks can be used to expand the list of likely trait associated genes from genome-wide association studies (GWAS). Here, we used improvements in SNP-to-gene mapping to perform network based expansion of trait associated genes for 1,002 human traits showing that thi...

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Literature Corpus work: 30abd0b5-433a-5f33-9cc2-0c6a19f52a18
DOI: 10.1101/2021.07.19.452924

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