Article
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature genetics - 1 Mar 2023
Barrio-Hernandez Inigo, Schwartzentruber Jeremy, Shrivastava Anjali, Del-Toro Noemi, Gonzalez Asier, Zhang Qian, Mountjoy Edward, Suveges Daniel, Ochoa David, Ghoussaini Maya, Bradley Glyn, Hermjakob Henning, Orchard Sandra, Dunham Ian, Anderson Carl A, Porras Pablo, Beltrao Pedro
Abstract excerpt
Interacting proteins tend to have similar functions, influencing the same organismal traits. Interaction networks can be used to expand the list of candidate trait-associated genes from genome-wide association studies. Here, we performed network-based expansion of trait-associated genes for 1,002 human traits showing that this recovers known disease genes or drug targets. The similarity of network expansion...
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