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Article

Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation.

2020-03-31

Abstract excerpt

<title>Abstract</title> <p>Background: Neurodegeneration is a representative phenotype of patients with chronic alcoholism. Ethanol-induced calcium overload causes NLRP3 inflammasome formation and an imbalance in mitochondrial dynamics, closely associated with the pathogenesis of neurodegeneration. However, how calcium regulates this process in neuronal cells is poorly understood. Therefore, the present study inv...

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Literature Corpus work
3097b782-d240-5ee7-8458-6e99a4f2ba4c
DOI
10.21203/rs.2.18316/v2
Open publication

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Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation.DOI 10.21203/rs.2.18316/v2
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