Article

Neuroinflammatory Responses and Blood–Brain Barrier Injury in Chronic Alcohol Exposure: Role of Purinergic P2X7 Receptor Signaling

2024-05-08

Abstract excerpt

<title>Abstract</title> <p>Alcohol consumption leads to neuroinflammation and blood‒brain barrier (BBB) damage, resulting in neurological impairment. We previously demonstrated that ethanol-induced disruption of barrier function in human brain endothelial cells was associated with mitochondrial injury, increased ATP and extracellular vesicle (EV) release, and purinergic receptor P2X7R activation. Therefore, we ai...

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Literature Corpus work: a895d292-6bc7-5f14-987f-b59a7e3b5b47
DOI: 10.21203/rs.3.rs-4350949/v1

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