Article

OGT controls mammalian cell viability by regulating the proteasome/mTOR/mitochondrial axis

2021-09-20

Abstract excerpt

O -GlcNAc transferase (OGT) catalyzes the modification of serine and threonine residues on nuclear and cytosolic proteins with O -linked N-acetylglucosamine (GlcNAc). OGT is essential for mammalian cell viability, but the underlying mechanisms are still enigmatic. We employed a genome-wide CRISPR-Cas9 viability screen in mouse embryonic stem cells (mESCs) with inducible Ogt gene deletion and showed that the bloc...

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Identifiers and source

Literature Corpus work: 30825320-3317-557c-8af7-fe2bbe4204a4
DOI: 10.1101/2021.09.19.461012

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