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Article

Staufen Impairs Autophagy in Neurodegeneration

24 Sept 2022

Abstract excerpt

OBJECTIVE: The mechanistic target of rapamycin (mTOR) kinase is one of the master coordinators of cellular stress responses, regulating metabolism, autophagy, and apoptosis. We recently reported that staufen1 (STAU1), a stress granule (SG) protein, was overabundant in fibroblast cell lines from patients with spinocerebellar ataxia type 2 (SCA2), amyotrophic lateral sclerosis, frontotemporal degeneration,...

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PMID: 36151701
DOI: 10.1002/ana.26515

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