Article
STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis.
Annals of hematology - 1 Aug 2024
Yang Jichun, Shi Xiaofeng, Liu Xinyao, Qiao Xinrui, Zhou Xun, Li Hongmin, Du Yali, Chen Miao, Fang Dongdong, Han Bing, Long Zhangbiao
Abstract excerpt
Acquired pure red cell aplasia (PRCA) is anemia associated with the absence of erythroblasts and is characterized by persistent and easy recurrence. However, the underlying mechanisms of acquired PRCA remain obscure, and the role of gene mutations in the pathogenesis of acquired PRCA is not fully characterized. In the present study, we detected thirty newly diagnosed patients with acquired PRCA using whole exome...
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