Article

Genome-wide <i>in vivo</i> CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

2022-02-17

Abstract excerpt

Identifying tumor suppressor genes is predicted to inform on the development of novel strategies for cancer therapy. To identify new lymphoma driving processes that cooperate with oncogenic MYC (which is abnormally highly expressed in ∼70% of human cancers) we have used a genome-wide CRISPR knockout screen in Eµ-Myc;Cas9 transgenic hematopoietic stem and progenitor cells in vivo . We discovered that loss of any...

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Literature Corpus work: 3036b9cd-709e-560b-87ce-3b9abe2c4d16
DOI: 10.1101/2022.02.16.480657

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