Article

Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in the developing cochlea

2024-02-01

Abstract excerpt

Spiral ganglion neurons (SGNs) are the primary afferent neurons that convey sound information from the cochlea, but the epigenetic changes that occur during development are unknown. We identified the chromodomain helicase binding protein 4 (CHD4) expression in SGNs. CHD4 is an ATP-dependent chromatin remodeler. We employed the Neurog1 ( Ngn1 ) CreERT 2 Chd4 conditional knockout animals to investigate Chd4 func...

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Literature Corpus work: 30225bc1-d208-53d1-89e3-b967aff9ec34
DOI: 10.1101/2024.01.31.578202

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