Article

Low-dose IL-2 reduces IL-21<sup>+</sup>T cells and induces a long-lived anti-inflammatory gene expression signature inversely modulated in COVID-19 patients

2022-04-05

Abstract excerpt

Despite early clinical successes, the mechanisms of action of low-dose interleukin-2 (LD-IL-2) immunotherapy remain only partly understood. Here, we examined the effects of interval administration of low-dose recombinant IL-2 (iLD-IL-2) using high-resolution, single-cell multiomics and flow cytometry. We confirmed that iLD-IL-2 selectively expands thymic-derived FOXP3 + HELIOS + Tregs and CD56 br NK cells, and sho...

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Literature Corpus work: 3003a100-51db-5938-a61d-c2b063b8782f
DOI: 10.1101/2022.04.05.22273167

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