Article

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and gatekeeper features

2022-11-15

Abstract excerpt

<h4>ABSTRACT</h4> Due to its stimulatory potential for immunomodulatory CD4 + regulatory T (Treg) cells, low-dose interleukin-2 (IL-2) immunotherapy has recently gained considerable attention for treatment of various autoimmune diseases. Although early-stage clinical trials have correlated expansion of circulating Treg cells with clinical response to IL-2 treatment, detailed mechanistic data on responding Treg cel...

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Literature Corpus work: b04cde8e-8ec8-5a1b-aa26-1fe725be77a8
DOI: 10.1101/2022.11.15.22282201

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