Article

Rhomboid protease Rhbdl2 regulates macrophage recruitment and wound regeneration in zebrafish

2026-02-15

Abstract excerpt

Tissue regeneration requires tight control of immune cell behavior, yet the mechanisms that restrain immune-driven regenerative responses remain poorly defined. Here, we identify the rhomboid intramembrane serine protease Rhbdl2 as a critical regulator of regeneration in zebrafish. We generated rhbdl2 mutants by CRISPR-Cas9 and found that it does not affect normal development, but triggers enhanced regenerative g...

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Literature Corpus work: 2fff4234-165d-5405-8cdd-7baa4c5e873c
DOI: 10.64898/2026.02.13.705804

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