Article
Early induction of NRF2 antioxidant pathway by RHBDF2 mediates rapid cutaneous wound healing.
Experimental and molecular pathology - 1 Apr 2017
Hosur Vishnu, Burzenski Lisa M, Stearns Timothy M, Farley Michelle L, Sundberg John P, Wiles Michael V, Shultz Leonard D
Abstract excerpt
Rhomboid family protein RHBDF2, an upstream regulator of the epidermal growth factor (EGF) receptor signaling, has been implicated in cutaneous wound healing. However, the underlying molecular mechanisms are still emerging. In humans, a gain-of-function mutation in the RHBDF2 gene accelerates cutaneous wound healing in an EGFR-dependent manner. Likewise, a gain-of-function mutation in the mouse Rhbdf2 gene...
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