Article
Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 2014
Arneja Abhinav, Johnson Hannah, Gabrovsek Laura, Lauffenburger Douglas A, White Forest M
Abstract excerpt
IL-2 and IL-15 are common γ-chain family cytokines involved in regulation of T cell differentiation and homeostasis. Despite signaling through the same receptors, IL-2 and IL-15 have non-redundant roles in T cell biology, both physiologically and at the cellular level. The mechanisms by which IL-2 and IL-15 trigger distinct phenotypes in T cells remain elusive. To elucidate these mechanisms, we performed a...
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