Article

Temporal Vascular Endothelial Growth Factor Sub-type Gene Switching in SARS-CoV-related Inflammation - Basis for a Dual Gene Biomarker Approach

2022-11-07

Abstract excerpt

This study examines temporal gene expression (GE) patterns in a murine model of SARS-CoV infection. We focused on a Temporal Gene Set (TGS) comprising pro-inflammatory genes (TNF, NFKB1, VEGF-A) and VEGF-B. A systematic search of the NCBI Geo database for MA15 (SARS-CoV) pulmonary studies using C57BL Wild (WT) mice and filtering according to TGS GE patterns eluded seven datasets for further analysis. Encompassing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2feca8cc-d8f6-5cec-aab8-f9fdfee64994
DOI: 10.1101/2022.11.06.515327

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Temporal Vascular Endothelial Growth Factor Sub-type Gene Switching in SARS-CoV-related Inflammation - Basis for a Dual Gene Biomarker ApproachDOI 10.1101/2022.11.06.515327Read

ACE2 is the critical <i>in vivo</i> receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologySemantic proximity Read

A Four-Biomarker Blood Signature Discriminates Systemic Inflammation Due to Viral Infection Versus Other EtiologiesSemantic proximity Read

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathologySemantic proximity Read

Tissue factor upregulation is associated with SARS‐CoV‐2 in the lungs of COVID‐19 patientsSemantic proximity Read

Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionSemantic proximity Read

Multi-omics delineation of cytokine-induced endothelial inflammatory statesSemantic proximity Read

VEGF subtype A and B Gene Expression, Clues to a Temporal Signature in Kawasaki Disease, Implications for Coronary Pathogenesis through a Secondary analysis of Clinical DatasetsSemantic proximity Read

Coping With Stress: The Mitokine GDF-15 as a Biomarker of COVID-19 SeveritySemantic proximity Read

SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollutionSemantic proximity Read

Neural epidermal growth factor-like 1 protein variant increases survival and modulates the inflammatory and immune responses in human ACE-2 transgenic mice infected with SARS-CoV-2Semantic proximity Read

How Do Deer Respiratory Epithelial Cells Weather The Initial Storm of SARS-CoV-2?Semantic proximity Read

The host transcriptional response to superinfection by influenza A virus and Streptococcus pneumoniaeSemantic proximity Read