Article

SARS-CoV-2-induced impaired immune response by Prostaglandin E2 is accelerated by age, male sex and air pollution

2020-12-31

Abstract excerpt

<title>Abstract</title> <p>The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds prostaglandin E2 (PGE2) blood levels elevated in COVID-19 patients with positive correlation with disease severity. SARS-CoV-2 induces PGE2 generation and secretion in infected lung epithelial cells by upregulating cyclo-oxygenase (COX)-2 and reducing the PG-degrading enzyme 15-hyd...

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Literature Corpus work: 52f270d8-e9c8-5db2-a304-d990bc40d222
DOI: 10.21203/rs.3.rs-129664/v1

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