The host transcriptional response to superinfection by influenza A virus and Streptococcus pneumoniae

Abstract excerpt

ABSTRACT Secondary bacterial challenges during influenza virus infection “superinfection”) cause excessive mortality and hospitalization. Here, we present a longitudinal study of bulk gene expression changes in murine lungs during superinfection, with an initial influenza A virus infection and a subsequent Streptococcus pneumoniae infection. In addition to the well-characterized impairment of the host response,...

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