Article

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

2020-11-19

Abstract excerpt

Zoonotic pandemics, like that caused by SARS-CoV-2, can follow the spillover of animal viruses into highly susceptible human populations. Their descendants have adapted to the human host and evolved to evade immune pressure. Coronaviruses acquire substitutions more slowly than other RNA viruses, due to a proofreading polymerase. In the spike glycoprotein, we find recurrent deletions overcome this slow substitution...

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Literature Corpus work: 2fb1c5d1-5dc7-5df9-80db-25ed8cc74b26
DOI: 10.1101/2020.11.19.389916

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