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Article

Recurrent deletions in the SARS-CoV-2 spike glycoprotein drive antibody escape

11 Mar 2021

Abstract excerpt

Zoonotic pandemics, such as that caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can follow the spillover of animal viruses into highly susceptible human populations. The descendants of these viruses have adapted to the human host and evolved to evade immune pressure. Coronaviruses acquire substitutions more slowly than other RNA viruses. In the spike glycoprotein, we found that recurrent...

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PMID: 33536258
DOI: 10.1126/science.abf6950

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