Adapt or perish: SARS-CoV-2 antibody escape variants defined by deletions in the Spike N-terminal Domain

Abstract excerpt

In a recent report in Science , McCarthy et al. promptly observed a pattern of recurrent deletions in four discrete regions of the N-terminal Domain (NTD) of the Spike protein, which provide resistance to antibody neutralization, suggesting convergent evolution due to selective pressure and antigenic drift. 1

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