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Article

The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.

Scientific reports - 25 Jun 2024

Gabbert Carolin, Blöbaum Leonie, Lüth Theresa, König Inke R, Caliebe Amke, Sendel Sebastian, Laabs Björn-Hergen, Klein Christine, Trinh Joanne

Abstract excerpt

The objective of this study was to investigate the association between a Parkinson's disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4367 patients with idiopathic PD, 159 patients with GBA1-PD, and 3090 healthy controls of European ancestry from AMP-PD, PPMI, and Fox Insight cohorts. The association between PGS and lifestyle factors...

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Identifiers

PMID: 38918550
DOI: 10.1038/s41598-024-65640-x
PMCID: PMC11199580

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