Article
SREBP-1 as a Transcriptional Integrator of Circadian and Nutritional Cues in the Liver
25 Apr 2005
Abstract excerpt
The act of feeding in mammals can generate such powerful cues for peripheral organs that, under certain conditions, they can override the entraining signals coming from the clock in the brain. Restricting the feeding time to the inactivity period, for example, can completely and quickly reverse the rhythms of gene expression in the liver. This manipulation does not affect the central oscillator in the...
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