Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

7 Feb 2020

Abstract excerpt

Our understanding of the signalling pathways regulating early human development is limited, despite their fundamental biological importance. Here, we mine transcriptomics datasets to investigate signalling in the human embryo and identify expression for the insulin and insulin growth factor 1 (IGF1) receptors, along with IGF1 ligand. Consequently, we generate a minimal chemically-defined culture medium in which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pluripotent Stem Cells Research
Share to Renal and related cancers
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32034154
DOI: 10.1038/s41467-020-14629-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic nichePMID 32034154Read ↗

Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signalingSemantic proximity Read ↗

A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansionSemantic proximity Read ↗

A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansionSemantic proximity Read ↗

Spatially Organized IGF1-mTOR Signaling Controls Human Forebrain Progenitor Fate Through Coordinated Transcriptional and Translational ProgramsSemantic proximity Read ↗

Large scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal crosstalkSemantic proximity Read ↗

The Emerging Role of Insulin and Insulin-Like Growth Factor Signaling in Cancer Stem CellsSemantic proximity Read ↗

Suppression of ERK signalling promotes pluripotent epiblast in the human blastocystSemantic proximity Read ↗

Identification of Potential Pluripotency Determinants for Human Embryonic Stem Cells Following Proteomic Analysis of Human and Mouse Fibroblast Conditioned MediaSemantic proximity Read ↗

A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centreSemantic proximity Read ↗

Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potentialSemantic proximity Read ↗

Insulin-Like Growth Factor Promotes Cardiac Lineage Induction In Vitro by Selective Expansion of Early MesodermSemantic proximity Read ↗

Niche Modulation of IGF-1R Signaling: Its Role in Stem Cell Pluripotency, Cancer Reprogramming, and Therapeutic ApplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.