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Article

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer’s disease

10 Sept 2013

Abstract excerpt

Deposition of insoluble protein aggregates is a hallmark of neurodegenerative diseases. The universal presence of β-amyloid and tau in Alzheimer's disease (AD) has facilitated advancement of the amyloid cascade and tau hypotheses that have dominated AD pathogenesis research and therapeutic development. However, the underlying etiology of the disease remains to be fully elucidated. Here we report a comprehensive...

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PMID: 24023061
DOI: 10.1073/pnas.1310249110

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