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Article

Transcriptomic signatures of classical monocytes reveal pro-inflammatory modules and heterogeneity in polyarticular juvenile idiopathic arthritis.

Frontiers in immunology - 1 Jan 2024

Hounkpe Bidossessi W, Sales Lucas P, Ribeiro Surian C R, Perez Mariana O, Caparbo Valéria F, Domiciano Diogo Souza, Figueiredo Camille P, Pereira Rosa M R, Borba Eduardo F

Abstract excerpt

Introduction: Polyarticular juvenile idiopathic arthritis (pJIA) is a childhood-onset autoimmune disease. Immune cells contribute to persistent inflammation observed in pJIA. Despite the crucial role of monocytes in arthritis, the precise involvement of classical monocytes in the pathogenesis of pJIA remains uncertain. Here, we aimed to uncover the transcriptomic patterns of classical monocytes in pJIA, focusing...

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Share to Arthritis, Juvenile
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38835762
DOI: 10.3389/fimmu.2024.1400036
PMCID: PMC11148224

Genes

CDKN1A
ICAM1
IL1B
IL6
PIM1
PLAUR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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